Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.

Westaway, David; Genovesi, Sacha; Daude, Nathalie; Brown, Rebecca; Lau, Agnes; Lee, Inyoul; Mays, Charles E; Coomaraswamy, Janaky; Canine, Brenda; Pitstick, Rose; Herbst, Allen; Yang, Jing; Ko, Kerry W S; Schmitt-Ulms, Gerold; Dearmond, Stephen J; McKenzie, Debbie; Hood, Leroy; Carlson, George A

Westaway, David; Genovesi, Sacha; Daude, Nathalie; Brown, Rebecca; Lau, Agnes; Lee, Inyoul; Mays, Charles E; Coomaraswamy, Janaky; Canine, Brenda; Pitstick, Rose; Herbst, Allen; Yang, Jing; Ko, Kerry W S; Schmitt-Ulms, Gerold; Dearmond, Stephen J; McKenzie, Debbie; Hood, Leroy; Carlson, George A.

Affiliation

Westaway D; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.

PLoS Pathog ; 7(11): e1002391, 2011 Nov.

Article in En | MEDLINE | ID: mdl-22114562

Subject(s)

Brain/metabolism; Nerve Tissue Proteins/genetics; PrPSc Proteins/biosynthesis; Prion Diseases/metabolism; Animals; Down-Regulation; GPI-Linked Proteins/biosynthesis; GPI-Linked Proteins/genetics; Mice; Mice, Transgenic; Nerve Tissue Proteins/biosynthesis; PrPC Proteins/metabolism; RNA, Messenger/metabolism

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Full text: 1 Database: MEDLINE Main subject: Brain / Prion Diseases / PrPSc Proteins / Nerve Tissue Proteins Limits: Animals Language: En Journal: PLoS Pathog Year: 2011 Type: Article Affiliation country: Canada

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