Distinctive immunoregulatory effects of adenosine on T cells of older humans.

Hesdorffer, Charles S; Malchinkhuu, Enkhzol; Biragyn, Arya; Mabrouk, Omar S; Kennedy, Robert T; Madara, Karen; Taub, Dennis D; Longo, Dan L; Schwartz, Janice B; Ferrucci, Luigi; Goetzl, Edward J

Hesdorffer, Charles S; Malchinkhuu, Enkhzol; Biragyn, Arya; Mabrouk, Omar S; Kennedy, Robert T; Madara, Karen; Taub, Dennis D; Longo, Dan L; Schwartz, Janice B; Ferrucci, Luigi; Goetzl, Edward J.

Affiliation

Hesdorffer CS; National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.

FASEB J ; 26(3): 1301-10, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22121051

Subject(s)

Adenosine/immunology; Adenosine/pharmacology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; Adenine/analogs & derivatives; Adenine/pharmacology; Adenosine/analogs & derivatives; Adenosine/metabolism; Adenosine A2 Receptor Agonists/pharmacology; Adenosine A2 Receptor Antagonists/pharmacology; Adult; Age Factors; Aged; Aged, 80 and over; Antigens, CD/immunology; Antigens, CD/metabolism; Apyrase/immunology; Apyrase/metabolism; CD28 Antigens/immunology; CD28 Antigens/metabolism; Cells, Cultured; Chemotaxis/drug effects; Cytokines/immunology; Cytokines/metabolism; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Male; Middle Aged; Phenethylamines/pharmacology; Pyrimidines/pharmacology; T-Lymphocytes/metabolism; Triazoles/pharmacology; Young Adult

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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes / Adenosine Limits: Aged80 Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2012 Type: Article Affiliation country: United States

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