Consequences of alteration in leucine zipper sequence of melittin in its neutralization of lipopolysaccharide-induced proinflammatory response in macrophage cells and interaction with lipopolysaccharide.

Srivastava, Raghvendra M; Srivastava, Saurabh; Singh, Manish; Bajpai, Virendra Kumar; Ghosh, Jimut Kanti

Srivastava, Raghvendra M; Srivastava, Saurabh; Singh, Manish; Bajpai, Virendra Kumar; Ghosh, Jimut Kanti.

Affiliation

Srivastava RM; Molecular and Structural Biology Division, Sophisticated Analytical Instrument Facility, Central Drug Research Institute, Council of Scientific and Industrial Research, Chattar Manzil Palace, P. O. Box 173, Lucknow 226001, India.

J Biol Chem ; 287(3): 1980-95, 2012 Jan 13.

Article in En | MEDLINE | ID: mdl-22128186

Subject(s)

Lipopolysaccharides/pharmacology; Macrophages/metabolism; Melitten/genetics; Melitten/pharmacology; Amino Acid Substitution; Animals; Cell Line; Cytokines/biosynthesis; Cytokines/genetics; Inflammation/chemically induced; Inflammation/genetics; Inflammation/metabolism; Inflammation/pathology; Leucine Zippers/genetics; Lipopolysaccharides/antagonists & inhibitors; Macrophages/pathology; Melitten/metabolism; Mice; Mutation, Missense; Rats

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Full text: 1 Database: MEDLINE Main subject: Lipopolysaccharides / Macrophages / Melitten Limits: Animals Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: India

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