Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase.

Yu, Bing; Tang, Li-da; Li, Yi-Liang; Song, Shu-Hui; Ji, Xiao-Liang; Lin, Mu-Sen; Wu, Chun-Fu

Yu, Bing; Tang, Li-da; Li, Yi-Liang; Song, Shu-Hui; Ji, Xiao-Liang; Lin, Mu-Sen; Wu, Chun-Fu.

Affiliation

Yu B; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.

Bioorg Med Chem Lett ; 22(1): 110-4, 2012 Jan 01.

Article in En | MEDLINE | ID: mdl-22169262

Subject(s)

Chemistry, Pharmaceutical/methods; Quinazolines/pharmacology; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Animals; Antineoplastic Agents/pharmacology; Drug Design; Drug Screening Assays, Antitumor/methods; Enzyme Inhibitors/pharmacology; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Models, Chemical; Neoplasm Transplantation; Piperidines/pharmacology; Quinazolines/chemical synthesis; Vascular Endothelial Growth Factor Receptor-2/chemistry

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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Chemistry, Pharmaceutical / Vascular Endothelial Growth Factor Receptor-2 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article

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