Multiparameter exploration of piperazine derivatives as Î´-opioid receptor agonists for CNS indications.

McCauley, John P; Dantzman, Cathy L; King, Megan M; Ernst, Glen E; Wang, Xia; Brush, Kelly; Palmer, William E; Frietze, William; Andisik, Donald W; Hoesch, Valerie; Doring, Kenneth; Hulsizer, James; Bui, Khanh H; Liu, Jay; Hudzik, Thomas J; Wesolowski, Steven S

McCauley, John P; Dantzman, Cathy L; King, Megan M; Ernst, Glen E; Wang, Xia; Brush, Kelly; Palmer, William E; Frietze, William; Andisik, Donald W; Hoesch, Valerie; Doring, Kenneth; Hulsizer, James; Bui, Khanh H; Liu, Jay; Hudzik, Thomas J; Wesolowski, Steven S.

Affiliation

McCauley JP; AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850, USA.

Bioorg Med Chem Lett ; 22(2): 1169-73, 2012 Jan 15.

Article in En | MEDLINE | ID: mdl-22197139

Subject(s)

Central Nervous System/drug effects; Piperazines/pharmacology; Receptors, Opioid, delta/agonists; Animals; Central Nervous System/metabolism; Computer Simulation; Dogs; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Humans; Molecular Structure; Piperazines/chemical synthesis; Piperazines/chemistry; Receptors, Opioid, delta/metabolism; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Piperazines / Central Nervous System / Receptors, Opioid, delta Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United States

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