Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.

Bagley, Scott W; Southers, James A; Cabral, Shawn; Rose, Colin R; Bernhardson, David J; Edmonds, David J; Polivkova, Jana; Yang, Xiaojing; Kung, Daniel W; Griffith, David A; Bader, Scott J

Bagley, Scott W; Southers, James A; Cabral, Shawn; Rose, Colin R; Bernhardson, David J; Edmonds, David J; Polivkova, Jana; Yang, Xiaojing; Kung, Daniel W; Griffith, David A; Bader, Scott J.

Affiliation

Bagley SW; Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, USA. Scott.W.Bagley@Pfizer.com

J Org Chem ; 77(3): 1497-506, 2012 Feb 03.

Article in En | MEDLINE | ID: mdl-22239115

Subject(s)

Acetyl-CoA Carboxylase/antagonists & inhibitors; Chemistry Techniques, Synthetic/methods; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Indazoles/chemical synthesis; Indazoles/pharmacology; Piperidines/chemical synthesis; Piperidines/pharmacology; Alkenes/chemistry; Alkylation; Enzyme Inhibitors/chemistry; Indazoles/chemistry; Ketones/chemistry; Piperidines/chemistry; Pyrazoles/chemistry; Stereoisomerism; Substrate Specificity

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Full text: 1 Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Piperidines / Enzyme Inhibitors / Chemistry Techniques, Synthetic / Indazoles Language: En Journal: J Org Chem Year: 2012 Type: Article Affiliation country: United States

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