The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a.

Cameron, Amy R; Wallace, Katherine; Logie, Lisa; Prescott, Alan R; Unterman, Terry G; Harthill, Jean; Rena, Graham

Cameron, Amy R; Wallace, Katherine; Logie, Lisa; Prescott, Alan R; Unterman, Terry G; Harthill, Jean; Rena, Graham.

Affiliation

Cameron AR; Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.

Biochem J ; 443(1): 57-64, 2012 Apr 01.

Article in En | MEDLINE | ID: mdl-22248233

Subject(s)

Clioquinol/pharmacology; Forkhead Transcription Factors/metabolism; Neuroprotective Agents/pharmacology; Active Transport, Cell Nucleus; Forkhead Box Protein O1; Gene Expression Regulation/drug effects; Gluconeogenesis/genetics; HEK293 Cells; Humans; Hydroxyquinolines/pharmacology; Phosphorylation; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Structure-Activity Relationship; Zinc/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Clioquinol / Neuroprotective Agents / Forkhead Transcription Factors Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biochem J Year: 2012 Type: Article Affiliation country: United kingdom

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