SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.

Tahlan, Kapil; Wilson, Regina; Kastrinsky, David B; Arora, Kriti; Nair, Vinod; Fischer, Elizabeth; Barnes, S Whitney; Walker, John R; Alland, David; Barry, Clifton E; Boshoff, Helena I

Tahlan, Kapil; Wilson, Regina; Kastrinsky, David B; Arora, Kriti; Nair, Vinod; Fischer, Elizabeth; Barnes, S Whitney; Walker, John R; Alland, David; Barry, Clifton E; Boshoff, Helena I.

Affiliation

Tahlan K; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute for Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.

Antimicrob Agents Chemother ; 56(4): 1797-809, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22252828

Subject(s)

Adamantane/analogs & derivatives; Antitubercular Agents/pharmacology; Bacterial Proteins/drug effects; Cell Wall/metabolism; Cord Factors/metabolism; Ethylenediamines/pharmacology; Membrane Transport Proteins/drug effects; Mycobacterium tuberculosis/metabolism; Mycolic Acids/metabolism; Acyltransferases/metabolism; Adamantane/pharmacology; Aerobiosis; Antigens, Bacterial/metabolism; Cell Wall/drug effects; Chromatography, Thin Layer; Drug Resistance, Bacterial/genetics; Lipid Metabolism; Microbial Sensitivity Tests; Microscopy, Electron; Mutation/genetics; Mycobacterium tuberculosis/drug effects; Mycobacterium tuberculosis/ultrastructure

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Full text: 1 Database: MEDLINE Main subject: Membrane Transport Proteins / Bacterial Proteins / Adamantane / Cell Wall / Cord Factors / Ethylenediamines / Mycobacterium tuberculosis / Mycolic Acids / Antitubercular Agents Language: En Journal: Antimicrob Agents Chemother Year: 2012 Type: Article Affiliation country: United States

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