LPS regulates SOCS2 transcription in a type I interferon dependent autocrine-paracrine loop.

Hu, Jin; Lou, DaoHua; Carow, Berit; Winerdal, Malin E; Rottenberg, Martin; Wikström, Ann-Charlotte; Norstedt, Gunnar; Winqvist, Ola

Hu, Jin; Lou, DaoHua; Carow, Berit; Winerdal, Malin E; Rottenberg, Martin; Wikström, Ann-Charlotte; Norstedt, Gunnar; Winqvist, Ola.

Affiliation

Hu J; Translational Immunology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

PLoS One ; 7(1): e30166, 2012.

Article in En | MEDLINE | ID: mdl-22291912

Subject(s)

Autocrine Communication/drug effects; Interferon Type I/pharmacology; Lipopolysaccharides/pharmacology; Paracrine Communication/drug effects; Suppressor of Cytokine Signaling Proteins/genetics; Animals; Autocrine Communication/genetics; Autocrine Communication/physiology; Cells, Cultured; Gene Expression Regulation/drug effects; Humans; Interferon Regulatory Factor-3/genetics; Interferon Type I/metabolism; Macrophages/drug effects; Macrophages/metabolism; Macrophages/physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88/genetics; Paracrine Communication/genetics; Paracrine Communication/physiology; STAT Transcription Factors/genetics; STAT Transcription Factors/metabolism; Suppressor of Cytokine Signaling Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Interferon Type I / Lipopolysaccharides / Autocrine Communication / Paracrine Communication / Suppressor of Cytokine Signaling Proteins Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: Sweden

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