Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.

Liu, Shenping; Ammirati, Mark J; Song, Xi; Knafels, John D; Zhang, Jeff; Greasley, Samantha E; Pfefferkorn, Jeffrey A; Qiu, Xiayang

Liu, Shenping; Ammirati, Mark J; Song, Xi; Knafels, John D; Zhang, Jeff; Greasley, Samantha E; Pfefferkorn, Jeffrey A; Qiu, Xiayang.

Affiliation

Liu S; Structural Biology and Biophysics, Pfizer Groton Laboratories, Groton, Connecticut 06340, USA. shenping.liu@pfizer.com

J Biol Chem ; 287(17): 13598-610, 2012 Apr 20.

Article in En | MEDLINE | ID: mdl-22298776

Subject(s)

Gene Expression Regulation; Glucokinase/metabolism; Glucose/chemistry; Allosteric Site; Catalysis; Enzyme Activation; Homeostasis; Humans; Hypoglycemia/pathology; Kinetics; Models, Biological; Models, Molecular; Mutation; Protein Conformation; Scattering, Radiation; X-Rays

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Full text: 1 Database: MEDLINE Main subject: Gene Expression Regulation / Glucokinase / Glucose Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: United States

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