Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity.

Correa, Rohann J M; Komar, Monica; Tong, Jessica G K; Sivapragasam, Milani; Rahman, Masmudur M; McFadden, Grant; Dimattia, Gabriel E; Shepherd, Trevor G

Correa, Rohann J M; Komar, Monica; Tong, Jessica G K; Sivapragasam, Milani; Rahman, Masmudur M; McFadden, Grant; Dimattia, Gabriel E; Shepherd, Trevor G.

Affiliation

Correa RJ; Translational Ovarian Cancer Research Program, London Regional Cancer Program, London, Ontario, Canada.

Gynecol Oncol ; 125(2): 441-50, 2012 May.

Article in En | MEDLINE | ID: mdl-22306204

Subject(s)

Myxoma virus/physiology; Neoplasms, Glandular and Epithelial/therapy; Oncogene Protein v-akt/metabolism; Oncolytic Virotherapy/methods; Ovarian Neoplasms/therapy; Ascites/pathology; Carcinoma, Ovarian Epithelial; Female; Green Fluorescent Proteins/biosynthesis; Green Fluorescent Proteins/genetics; Humans; Microscopy, Fluorescence/methods; Myxoma virus/genetics; Myxoma virus/metabolism; Neoplasms, Glandular and Epithelial/enzymology; Neoplasms, Glandular and Epithelial/virology; Ovarian Neoplasms/enzymology; Ovarian Neoplasms/virology; Phosphatidylinositol 3-Kinases/metabolism; Spheroids, Cellular/pathology; Tumor Cells, Cultured

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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms / Neoplasms, Glandular and Epithelial / Oncogene Protein v-akt / Oncolytic Virotherapy / Myxoma virus Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Gynecol Oncol Year: 2012 Type: Article Affiliation country: Canada

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