Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy.

Milner, Erin; Sousa, Jason; Pybus, Brandon; Auschwitz, Jennifer; Caridha, Diana; Gardner, Sean; Grauer, Kristina; Harris, Erin; Hickman, Mark; Kozar, Michael P; Lee, Patricia; Leed, Susan; Li, Qigui; Melendez, Victor; Moon, Jay; Ngundam, Franklyn; O'Neil, Michael; Parriott, Sandi; Potter, Brittney; Sciotti, Rick; Tangteung, Anchalee; Dow, Geoffrey S

Milner, Erin; Sousa, Jason; Pybus, Brandon; Auschwitz, Jennifer; Caridha, Diana; Gardner, Sean; Grauer, Kristina; Harris, Erin; Hickman, Mark; Kozar, Michael P; Lee, Patricia; Leed, Susan; Li, Qigui; Melendez, Victor; Moon, Jay; Ngundam, Franklyn; O'Neil, Michael; Parriott, Sandi; Potter, Brittney; Sciotti, Rick; Tangteung, Anchalee; Dow, Geoffrey S.

Affiliation

Milner E; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. erin.milner@amedd.army.mil

Eur J Drug Metab Pharmacokinet ; 37(1): 17-22, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22314893

Subject(s)

Antimalarials/pharmacology; Ketotifen/analogs & derivatives; Ketotifen/pharmacology; Malaria/drug therapy; Animals; Antimalarials/administration & dosage; Antimalarials/pharmacokinetics; Female; Humans; Inhibitory Concentration 50; Ketotifen/administration & dosage; Ketotifen/pharmacokinetics; Liver/parasitology; Malaria/parasitology; Malaria, Falciparum/drug therapy; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Parasitic Sensitivity Tests; Plasmodium berghei/drug effects; Plasmodium berghei/isolation & purification; Plasmodium falciparum/drug effects; Plasmodium falciparum/isolation & purification; Prodrugs

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Database: MEDLINE Main subject: Ketotifen / Malaria / Antimalarials Limits: Animals / Female / Humans / Male Language: En Journal: Eur J Drug Metab Pharmacokinet Year: 2012 Type: Article Affiliation country: United States

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