Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.

Tang, Xiaojing; Orlicky, Stephen; Mittag, Tanja; Csizmok, Veronika; Pawson, Tony; Forman-Kay, Julie D; Sicheri, Frank; Tyers, Mike

Tang, Xiaojing; Orlicky, Stephen; Mittag, Tanja; Csizmok, Veronika; Pawson, Tony; Forman-Kay, Julie D; Sicheri, Frank; Tyers, Mike.

Affiliation

Tang X; Center for Systems Biology, Samuel Lunenfeld Research Institute, Toronto, ON, Canada M5G 1X5.

Proc Natl Acad Sci U S A ; 109(9): 3287-92, 2012 Feb 28.

Article in En | MEDLINE | ID: mdl-22328159

Subject(s)

Cell Cycle Proteins/metabolism; Cyclin-Dependent Kinase Inhibitor Proteins/metabolism; F-Box Proteins/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae/enzymology; Ubiquitin-Protein Ligases/metabolism; Amino Acid Motifs; Amino Acid Sequence; Cell Cycle Proteins/chemistry; Cell Cycle Proteins/genetics; Consensus Sequence; Cyclin-Dependent Kinase Inhibitor Proteins/chemistry; Cyclin-Dependent Kinase Inhibitor Proteins/genetics; F-Box Proteins/chemistry; F-Box Proteins/genetics; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Phosphorylation; Protein Conformation; Protein Interaction Mapping; Protein Processing, Post-Translational; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/chemistry; Saccharomyces cerevisiae Proteins/genetics; Static Electricity; Surface Plasmon Resonance; Ubiquitin-Protein Ligases/chemistry; Ubiquitin-Protein Ligases/genetics

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Full text: 1 Database: MEDLINE Main subject: Saccharomyces cerevisiae / Cell Cycle Proteins / Saccharomyces cerevisiae Proteins / Ubiquitin-Protein Ligases / F-Box Proteins / Cyclin-Dependent Kinase Inhibitor Proteins Language: En Journal: Proc Natl Acad Sci U S A Year: 2012 Type: Article

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