Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.

Krueger, A Chris; Madigan, Darold L; Beno, David W; Betebenner, David A; Carrick, Robert; Green, Brian E; He, Wenping; Liu, Dachun; Maring, Clarence J; McDaniel, Keith F; Mo, Hongmei; Molla, Akhteruzzaman; Motter, Christopher E; Pilot-Matias, Tami J; Tufano, Michael D; Kempf, Dale J

Krueger, A Chris; Madigan, Darold L; Beno, David W; Betebenner, David A; Carrick, Robert; Green, Brian E; He, Wenping; Liu, Dachun; Maring, Clarence J; McDaniel, Keith F; Mo, Hongmei; Molla, Akhteruzzaman; Motter, Christopher E; Pilot-Matias, Tami J; Tufano, Michael D; Kempf, Dale J.

Affiliation

Krueger AC; Abbott Labs, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. a.chris.krueger@abbott.com

Bioorg Med Chem Lett ; 22(6): 2212-5, 2012 Mar 15.

Article in En | MEDLINE | ID: mdl-22342631

Subject(s)

Antiviral Agents/chemical synthesis; Hepacivirus/drug effects; Pyrimidines/chemical synthesis; RNA, Viral/antagonists & inhibitors; Antiviral Agents/pharmacology; Cell Line, Tumor; Genotype; Hepacivirus/physiology; Humans; Pyrimidines/pharmacology; RNA, Viral/biosynthesis; Replicon/drug effects; Structure-Activity Relationship; Virus Replication/drug effects

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Pyrimidines / RNA, Viral / Hepacivirus Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: United States

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