Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge.

Clay, Candice; Donart, Nathan; Fomukong, Ndingsa; Knight, Jennifer B; Lei, Wanli; Price, Lance; Hahn, Fletcher; Van Westrienen, Jesse; Harrod, Kevin S

Clay, Candice; Donart, Nathan; Fomukong, Ndingsa; Knight, Jennifer B; Lei, Wanli; Price, Lance; Hahn, Fletcher; Van Westrienen, Jesse; Harrod, Kevin S.

Affiliation

Clay C; Lovelace Respiratory Research Institute, Infectious Disease Program, Albuquerque, New Mexico, USA.

J Virol ; 86(8): 4234-44, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22345460

Subject(s)

Coronavirus/immunology; Pneumonia/immunology; Pneumonia/virology; Severe Acute Respiratory Syndrome/immunology; Severe Acute Respiratory Syndrome/virology; Virus Replication; Animals; Antibodies, Viral/immunology; Cell Line; Chlorocebus aethiops; Cytokines/metabolism; Dendritic Cells/immunology; Humans; Immunoglobulin A/immunology; Immunoglobulin G/immunology; Lung/immunology; Lung/pathology; Lung/virology; Macrophage Activation/immunology; Macrophages/immunology; Membrane Glycoproteins/immunology; Monocytes/immunology; Pneumonia/pathology; Severe Acute Respiratory Syndrome/metabolism; Spike Glycoprotein, Coronavirus; T-Lymphocytes/immunology; Viral Envelope Proteins/immunology

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Full text: 1 Database: MEDLINE Main subject: Pneumonia / Virus Replication / Coronavirus / Severe Acute Respiratory Syndrome Limits: Animals / Humans Language: En Journal: J Virol Year: 2012 Type: Article Affiliation country: United States

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