Daptomycin versus vancomycin in a methicillin-resistant Staphylococcus aureus endophthalmitis rabbit model: bactericidal effect, safety, and ocular pharmacokinetics.

Lefèvre, Sophie; Saleh, Maher; Marcellin, Luc; Subilia, Audrey; Bourcier, Tristan; Prévost, Gilles; Jehl, François

Lefèvre, Sophie; Saleh, Maher; Marcellin, Luc; Subilia, Audrey; Bourcier, Tristan; Prévost, Gilles; Jehl, François.

Affiliation

Lefèvre S; Institute of Bacteriology, University of Strasbourg, Strasbourg, France. sophie.lefevre@chru-strasbourg.fr

Antimicrob Agents Chemother ; 56(5): 2485-92, 2012 May.

Article in En | MEDLINE | ID: mdl-22371888

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Daptomycin/pharmacokinetics; Endophthalmitis/drug therapy; Methicillin-Resistant Staphylococcus aureus/drug effects; Staphylococcal Infections/drug therapy; Vancomycin/pharmacokinetics; Animals; Anti-Bacterial Agents/administration & dosage; Biological Availability; Colony Count, Microbial; Daptomycin/administration & dosage; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Endophthalmitis/microbiology; Endophthalmitis/pathology; Eye/drug effects; Eye/microbiology; Eye/pathology; Female; Half-Life; Intravitreal Injections; Methicillin-Resistant Staphylococcus aureus/physiology; Microbial Sensitivity Tests; Rabbits; Severity of Illness Index; Staphylococcal Infections/microbiology; Staphylococcal Infections/pathology; Vancomycin/administration & dosage

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Full text: 1 Database: MEDLINE Main subject: Staphylococcal Infections / Vancomycin / Endophthalmitis / Daptomycin / Methicillin-Resistant Staphylococcus aureus / Anti-Bacterial Agents Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2012 Type: Article Affiliation country: France

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