An investigation into the utility of a multi-compartmental, dynamic, system of the upper gastrointestinal tract to support formulation development and establish bioequivalence of poorly soluble drugs.

Dickinson, Paul A; Abu Rmaileh, Ragheb; Ashworth, Lee; Barker, Richard A; Burke, Wendy M; Patterson, Claire M; Stainforth, Nick; Yasin, Mohammed

Dickinson, Paul A; Abu Rmaileh, Ragheb; Ashworth, Lee; Barker, Richard A; Burke, Wendy M; Patterson, Claire M; Stainforth, Nick; Yasin, Mohammed.

Affiliation

Dickinson PA; Clinical Science, AstraZeneca R&D, Alderley Park, Macclesfield, UK. paul.dickinson@astrazeneca.com

AAPS J ; 14(2): 196-205, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22374384

Subject(s)

Chemistry, Pharmaceutical; Models, Biological; Morpholines/chemistry; Morpholines/pharmacokinetics; Upper Gastrointestinal Tract/metabolism; Animals; Caco-2 Cells; Cats; Chemistry, Pharmaceutical/trends; Dogs; Dose-Response Relationship, Drug; Humans; Morpholines/blood; Solubility; Swine; Therapeutic Equivalency; Upper Gastrointestinal Tract/drug effects

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Chemistry, Pharmaceutical / Morpholines / Upper Gastrointestinal Tract / Models, Biological Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: AAPS J Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2012 Type: Article Affiliation country: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google