Bioadhesive pellets increase local 5-aminosalicylic acid concentration in experimental colitis.

Bautzová, Tereza; Rabisková, Miloslava; Béduneau, Arnaud; Pellequer, Yann; Lamprecht, Alf

Bautzová, Tereza; Rabisková, Miloslava; Béduneau, Arnaud; Pellequer, Yann; Lamprecht, Alf.

Affiliation

Bautzová T; Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.

Eur J Pharm Biopharm ; 81(2): 379-85, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22386911

Subject(s)

Chitosan/administration & dosage; Chitosan/chemistry; Colitis/metabolism; Mesalamine/administration & dosage; Mesalamine/chemistry; Animals; Anti-Inflammatory Agents/administration & dosage; Anti-Inflammatory Agents/chemistry; Biopolymers/administration & dosage; Biopolymers/chemistry; Biopolymers/pharmacokinetics; Chitosan/pharmacokinetics; Colitis/drug therapy; Colon/drug effects; Colon/metabolism; Drug Delivery Systems/methods; Drug Implants/administration & dosage; Drug Implants/chemistry; Drug Implants/pharmacokinetics; Hydrogen-Ion Concentration; Inflammation/drug therapy; Inflammation/metabolism; Male; Mesalamine/pharmacokinetics; Particle Size; Peroxidase/metabolism; Rats; Rats, Wistar; Solubility

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Full text: 1 Database: MEDLINE Main subject: Colitis / Mesalamine / Chitosan Limits: Animals Language: En Journal: Eur J Pharm Biopharm Journal subject: FARMACIA / FARMACOLOGIA Year: 2012 Type: Article Affiliation country: Czech Republic

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