Alzheimer Disease/genetics; Genetic Predisposition to Disease/genetics; Membrane Proteins/genetics; Nerve Tissue Proteins/genetics; Polymorphism, Single Nucleotide/genetics; Aged; Aged, 80 and over; Alzheimer Disease/complications; Alzheimer Disease/metabolism; Amyloid beta-Protein Precursor/metabolism; Apolipoprotein E3/genetics; Caribbean Region; Chi-Square Distribution; Cognition Disorders/etiology; Cognition Disorders/genetics; Female; Gene Expression Regulation/genetics; Genetic Association Studies; HEK293 Cells/drug effects; HEK293 Cells/metabolism; Hispanic or Latino/genetics; Histone Acetyltransferases/metabolism; Humans; Linkage Disequilibrium; Lysine Acetyltransferase 5; Male; Mental Status Schedule; National Institute on Aging (U.S.); Nerve Tissue Proteins/metabolism; Neuropsychological Tests; Nuclear Proteins/metabolism; RNA, Small Interfering/metabolism; Transfection/methods; United States