Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus.

Diaconu, Iulia; Cerullo, Vincenzo; Hirvinen, Mari L M; Escutenaire, Sophie; Ugolini, Matteo; Pesonen, Saila K; Bramante, Simona; Parviainen, Suvi; Kanerva, Anna; Loskog, Angelica S I; Eliopoulos, Aristides G; Pesonen, Sari; Hemminki, Akseli

Diaconu, Iulia; Cerullo, Vincenzo; Hirvinen, Mari L M; Escutenaire, Sophie; Ugolini, Matteo; Pesonen, Saila K; Bramante, Simona; Parviainen, Suvi; Kanerva, Anna; Loskog, Angelica S I; Eliopoulos, Aristides G; Pesonen, Sari; Hemminki, Akseli.

Affiliation

Diaconu I; Cancer Gene Therapy Group, Molecular Cancer Biology Program & Transplantation Laboratory & Haartman Institute & Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.

Cancer Res ; 72(9): 2327-38, 2012 May 01.

Article in En | MEDLINE | ID: mdl-22396493

Subject(s)

CD40 Ligand/genetics; CD40 Ligand/immunology; Neoplasms/immunology; Neoplasms/therapy; Oncolytic Virotherapy/methods; Oncolytic Viruses/genetics; Oncolytic Viruses/immunology; Animals; Apoptosis/immunology; Cell Line, Tumor; Cytokines/immunology; Humans; Melanoma, Experimental/genetics; Melanoma, Experimental/immunology; Melanoma, Experimental/therapy; Melanoma, Experimental/virology; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasms/genetics; Neoplasms/virology; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Helper-Inducer/immunology; Urinary Bladder Neoplasms/genetics; Urinary Bladder Neoplasms/immunology; Urinary Bladder Neoplasms/therapy; Urinary Bladder Neoplasms/virology; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: CD40 Ligand / Oncolytic Viruses / Oncolytic Virotherapy / Neoplasms Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2012 Type: Article Affiliation country: Finland

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