Exclusive antagonism of the &#945;4 ß7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates.

Fedyk, Eric R; Wyant, Tim; Yang, Li-Li; Csizmadia, Vilmos; Burke, Kristine; Yang, Hua; Kadambi, Vivek J

Exclusive antagonism of the α4 ß7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates.

Fedyk, Eric R; Wyant, Tim; Yang, Li-Li; Csizmadia, Vilmos; Burke, Kristine; Yang, Hua; Kadambi, Vivek J.

Affiliation

Fedyk ER; Department of Drug Safety Evaluation, A Takeda Company, Cambridge, Massachusetts 02139, USA. Eric.Fedyk@mpi.com

Inflamm Bowel Dis ; 18(11): 2107-19, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22419649

Subject(s)

Antibodies, Monoclonal, Humanized/therapeutic use; Gastrointestinal Tract/drug effects; Inflammatory Bowel Diseases/drug therapy; Integrins/antagonists & inhibitors; Intestinal Mucosa/drug effects; Leukocytes/drug effects; Animals; Female; Gastrointestinal Tract/immunology; Gastrointestinal Tract/metabolism; Inflammatory Bowel Diseases/immunology; Inflammatory Bowel Diseases/metabolism; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Leukocytes/immunology; Leukocytes/metabolism; Macaca fascicularis; Male; Natalizumab; T-Lymphocytes, Helper-Inducer/drug effects; T-Lymphocytes, Helper-Inducer/immunology; T-Lymphocytes, Helper-Inducer/metabolism

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Full text: 1 Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Integrins / Gastrointestinal Tract / Antibodies, Monoclonal, Humanized / Intestinal Mucosa / Leukocytes Limits: Animals Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2012 Type: Article Affiliation country: United States

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