The fusion protein of IFN-&#945; and apolipoprotein A-I crosses the blood-brain barrier by a saturable transport mechanism.

Fioravanti, Jessica; Medina-Echeverz, José; Ardaiz, Nuria; Gomar, Celia; Parra-Guillén, Zinnia P; Prieto, Jesús; Berraondo, Pedro

The fusion protein of IFN-α and apolipoprotein A-I crosses the blood-brain barrier by a saturable transport mechanism.

Fioravanti, Jessica; Medina-Echeverz, José; Ardaiz, Nuria; Gomar, Celia; Parra-Guillén, Zinnia P; Prieto, Jesús; Berraondo, Pedro.

Affiliation

Fioravanti J; Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra, Pamplona, Navarra 31008, Spain.

J Immunol ; 188(8): 3988-92, 2012 Apr 15.

Article in En | MEDLINE | ID: mdl-22422884

Subject(s)

Apolipoprotein A-I/metabolism; Blood-Brain Barrier/metabolism; Interferon-alpha/metabolism; Recombinant Fusion Proteins/pharmacokinetics; Animals; Apolipoprotein A-I/genetics; Depression/drug therapy; Depression/etiology; Female; Half-Life; Hindlimb Suspension; Humans; Injections, Intravenous; Interferon-alpha/genetics; Lipoproteins, HDL/metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Transport; Recombinant Fusion Proteins/genetics

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Full text: 1 Database: MEDLINE Main subject: Recombinant Fusion Proteins / Blood-Brain Barrier / Interferon-alpha / Apolipoprotein A-I Type of study: Etiology_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunol Year: 2012 Type: Article Affiliation country: Spain

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