Axons/ultrastructure; GTP Phosphohydrolases/genetics; Mitochondria/pathology; Mitochondrial Proteins/genetics; Nerve Degeneration/genetics; Neurons/cytology; Point Mutation/genetics; Adaptor Proteins, Vesicular Transport/metabolism; Animals; Arginine/genetics; Calcium/metabolism; Deoxyglucose/metabolism; Embryo, Mammalian; Fluoresceins; GTP Phosphohydrolases/metabolism; Ganglia, Spinal/cytology; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Glutamine/genetics; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Humans; Mitochondria/drug effects; Mitochondria/ultrastructure; Nerve Degeneration/pathology; Nerve Degeneration/prevention & control; Nerve Tissue Proteins/metabolism; Neurons/ultrastructure; RNA, Small Interfering/pharmacology; Rats; Reactive Oxygen Species/metabolism; Sodium Channel Blockers/therapeutic use; Tetrodotoxin/therapeutic use; Transfection