Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation.
Immunity
; 36(5): 847-56, 2012 May 25.
Article
in En
| MEDLINE
| ID: mdl-22464171
ABSTRACT
T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC) formation and long-lived antibody responses. However, the cellular and molecular mechanisms that control Tfh cell differentiation in vivo are incompletely understood. Here we show that interleukin-2 (IL-2) administration impaired influenza-specific GCs, long-lived IgG responses, and Tfh cells. IL-2 did not directly inhibit GC formation, but instead suppressed the differentiation of Tfh cells, thereby hindering the maintenance of influenza-specific GC B cells. Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses in vivo and regulates Tfh cell development.
Full text:
1
Database:
MEDLINE
Main subject:
Cell Differentiation
/
Interleukin-2
/
T-Lymphocytes, Helper-Inducer
/
Germinal Center
Limits:
Animals
Language:
En
Journal:
Immunity
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2012
Type:
Article
Affiliation country:
United States