Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle, Rhonda M; Stewart, Daniel P; Koss, Brian; Lynch, John; Milasta, Sandra; Bathina, Madhavi; Temirov, Jamshid; Cleland, Megan M; Pelletier, Stéphane; Schuetz, John D; Youle, Richard J; Green, Douglas R; Opferman, Joseph T

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle, Rhonda M; Stewart, Daniel P; Koss, Brian; Lynch, John; Milasta, Sandra; Bathina, Madhavi; Temirov, Jamshid; Cleland, Megan M; Pelletier, Stéphane; Schuetz, John D; Youle, Richard J; Green, Douglas R; Opferman, Joseph T.

Affiliation

Perciavalle RM; Department of Biochemistry, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

Nat Cell Biol ; 14(6): 575-83, 2012 Apr 29.

Article in En | MEDLINE | ID: mdl-22544066

Subject(s)

Mitochondria/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Adenosine Triphosphate/biosynthesis; Animals; Apoptosis; Cell Respiration; Cells, Cultured; Humans; Membrane Potentials; Mice; Microscopy, Electron, Transmission; Mitochondria/ultrastructure; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2/genetics; Proton-Translocating ATPases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins c-bcl-2 / Mitochondria Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2012 Type: Article Affiliation country: United States

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