An unusually cold active nitroreductase for prodrug activations.

Çelik, Ayhan; Yetis, Gülden

Çelik, Ayhan; Yetis, Gülden.

Affiliation

Çelik A; Gebze Institute of Technology, Department of Chemistry, 41400 Gebze-Kocaeli, Turkey. ayhancelik@gyte.edu.tr

Bioorg Med Chem ; 20(11): 3540-50, 2012 Jun 01.

Article in En | MEDLINE | ID: mdl-22546205

Subject(s)

Nitroreductases/metabolism; Prodrugs/metabolism; Staphylococcus saprophyticus/enzymology; Aniline Mustard/analogs & derivatives; Aniline Mustard/metabolism; Aziridines/metabolism; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Escherichia coli/genetics; Flavin Mononucleotide/metabolism; Hydrogen-Ion Concentration; Mass Spectrometry; Nitrofurazone/metabolism; Nitroreductases/genetics; Phylogeny; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Staphylococcus saprophyticus/genetics; Temperature

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Full text: 1 Database: MEDLINE Main subject: Nitroreductases / Prodrugs / Staphylococcus saprophyticus Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: Turkey

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