Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-&#954;B signalling.

Amyot, Julie; Semache, Meriem; Ferdaoussi, Mourad; Fontés, Ghislaine; Poitout, Vincent

Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.

Amyot, Julie; Semache, Meriem; Ferdaoussi, Mourad; Fontés, Ghislaine; Poitout, Vincent.

Affiliation

Amyot J; Montreal Diabetes Research Center, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Quebec, Canada.

PLoS One ; 7(4): e36200, 2012.

Article in En | MEDLINE | ID: mdl-22558381

Subject(s)

Gene Expression Regulation/drug effects; Insulin/genetics; Islets of Langerhans/drug effects; Lipopolysaccharides/pharmacology; NF-kappa B/metabolism; Signal Transduction/drug effects; Toll-Like Receptor 4/metabolism; Animals; Cell Line; Homeodomain Proteins/metabolism; Humans; In Vitro Techniques; Insulin/metabolism; Insulin Secretion; Islets of Langerhans/cytology; Islets of Langerhans/metabolism; Male; Mice; NF-kappa B/antagonists & inhibitors; RNA Precursors/genetics; RNA Precursors/metabolism; Rats; Toll-Like Receptor 4/deficiency; Trans-Activators/metabolism

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Gene Expression Regulation / Lipopolysaccharides / NF-kappa B / Islets of Langerhans / Toll-Like Receptor 4 / Insulin Limits: Animals / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: Canada

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