A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.

Johnstone, Andrea L; Reierson, Gillian W; Smith, Robin P; Goldberg, Jeffrey L; Lemmon, Vance P; Bixby, John L

Johnstone, Andrea L; Reierson, Gillian W; Smith, Robin P; Goldberg, Jeffrey L; Lemmon, Vance P; Bixby, John L.

Affiliation

Johnstone AL; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1400 NW 12th Ave, Miami, FL 33136, USA.

Mol Cell Neurosci ; 50(2): 125-35, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22561309

Subject(s)

Antipsychotic Agents/pharmacology; Neurites/drug effects; Phenothiazines/pharmacology; Piperazines/pharmacology; Regeneration/drug effects; Animals; Antipsychotic Agents/chemistry; Brain/physiology; CHO Cells; Calcium Signaling/drug effects; Calcium Signaling/physiology; Cell Line, Tumor; Cells, Cultured; Chondroitin Sulfate Proteoglycans/pharmacology; Cricetinae; Cricetulus; Gene Expression Profiling; Humans; Neurons/drug effects; Neurons/metabolism; Neurons/physiology; Oligonucleotide Array Sequence Analysis; Phenothiazines/chemistry; Piperazines/chemistry; Rats

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Full text: 1 Database: MEDLINE Main subject: Phenothiazines / Piperazines / Regeneration / Antipsychotic Agents / Neurites Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Neurosci Journal subject: BIOLOGIA MOLECULAR / NEUROLOGIA Year: 2012 Type: Article Affiliation country: United States

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