Reduced interferon (IFN)-&#945; conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.

Kempaiah, Prakasha; Anyona, Samuel B; Raballah, Evans; Davenport, Gregory C; Were, Tom; Hittner, James B; Ong'echa, John M; Perkins, Douglas J

Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.

Kempaiah, Prakasha; Anyona, Samuel B; Raballah, Evans; Davenport, Gregory C; Were, Tom; Hittner, James B; Ong'echa, John M; Perkins, Douglas J.

Affiliation

Kempaiah P; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, MSC10-5550, Albuquerque, NM 87131-0001, USA. PKempaiah@salud.unm.edu

Hum Genet ; 131(8): 1375-91, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22570109

Subject(s)

Anemia/genetics; Cause of Death; Genetic Predisposition to Disease; Haplotypes; Interferon-alpha/biosynthesis; Malaria/etiology; Anemia/complications; Base Sequence; Cell Line; DNA Primers; Female; Humans; Infant; Interferon-alpha/genetics; Longitudinal Studies; Male; Polymerase Chain Reaction

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Full text: 1 Database: MEDLINE Main subject: Haplotypes / Cause of Death / Interferon-alpha / Genetic Predisposition to Disease / Anemia / Malaria Type of study: Observational_studies / Risk_factors_studies Limits: Female / Humans / Infant / Male Language: En Journal: Hum Genet Year: 2012 Type: Article Affiliation country: United States

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