The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine.

Lihoradova, Olga; Kalveram, Birte; Indran, Sabarish V; Lokugamage, Nandadeva; Juelich, Terry L; Hill, Terence E; Tseng, Chien-Te K; Gong, Bin; Fukushi, Shuetsu; Morikawa, Shigeru; Freiberg, Alexander N; Ikegami, Tetsuro

Lihoradova, Olga; Kalveram, Birte; Indran, Sabarish V; Lokugamage, Nandadeva; Juelich, Terry L; Hill, Terence E; Tseng, Chien-Te K; Gong, Bin; Fukushi, Shuetsu; Morikawa, Shigeru; Freiberg, Alexander N; Ikegami, Tetsuro.

Affiliation

Lihoradova O; Department of Pathology, Galveston, TX, USA.

J Virol ; 86(14): 7650-61, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22573861

Subject(s)

Rift Valley fever virus/immunology; Viral Nonstructural Proteins/immunology; Viral Vaccines/immunology; eIF-2 Kinase/immunology; Animals; Antibodies, Neutralizing/immunology; Cell Line; Chemokines/blood; Chlorocebus aethiops; Cricetinae; Dendritic Cells/immunology; Interferon-alpha/blood; Interferon-gamma/blood; Interleukin-17/blood; Interleukin-5/blood; Mice; Mutation; Rift Valley fever virus/genetics; Rift Valley fever virus/pathogenicity; Vero Cells; eIF-2 Kinase/antagonists & inhibitors

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Full text: 1 Database: MEDLINE Main subject: Rift Valley fever virus / Viral Vaccines / Viral Nonstructural Proteins / EIF-2 Kinase Limits: Animals Language: En Journal: J Virol Year: 2012 Type: Article Affiliation country: United States

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