The cytoplasmic AID complex.
Semin Immunol
; 24(4): 273-80, 2012 Aug.
Article
in En
| MEDLINE
| ID: mdl-22698843
ABSTRACT
Although AID fulfils its physiological function of diversifying antibody genes in the nucleus, most of the AID protein within the cell is found in a complex located in the cytoplasm. In this review, we summarize what is currently known about this cytoplasmic AID complex. Its size has been estimated to lie between 300 and 500kDa (sedimentation coefficient of 10-11S) and it comprises the abundant protein translation elongation factor 1α (eEF1A) as a major stoichiometric component. We speculate on the possible roles of this complex as well as of chaperones known to interact with AID in regulating the cytosolic retention of AID and its controlled release for import into the nucleus.
Full text:
1
Database:
MEDLINE
Main subject:
Cytidine Deaminase
/
Cytoplasm
Limits:
Animals
/
Humans
Language:
En
Journal:
Semin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2012
Type:
Article
Affiliation country:
United kingdom