Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response.

Jiang, Xiaomo; Kinch, Lisa N; Brautigam, Chad A; Chen, Xiang; Du, Fenghe; Grishin, Nick V; Chen, Zhijian J

Jiang, Xiaomo; Kinch, Lisa N; Brautigam, Chad A; Chen, Xiang; Du, Fenghe; Grishin, Nick V; Chen, Zhijian J.

Affiliation

Jiang X; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

Immunity ; 36(6): 959-73, 2012 Jun 29.

Article in En | MEDLINE | ID: mdl-22705106

Subject(s)

DEAD-box RNA Helicases/physiology; Encephalomyocarditis virus/physiology; Polyubiquitin/metabolism; Animals; Cell-Free System; DEAD Box Protein 58; DEAD-box RNA Helicases/chemistry; DEAD-box RNA Helicases/genetics; Encephalomyocarditis virus/genetics; Fibroblasts/metabolism; Fibroblasts/virology; HEK293 Cells/metabolism; HEK293 Cells/virology; Humans; Interferon Regulatory Factor-3/metabolism; Interferon-Induced Helicase, IFIH1; Interferon-beta/biosynthesis; Interferon-beta/genetics; Mice; Multiprotein Complexes; Mutagenesis, Site-Directed; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; RNA, Viral/metabolism; Receptors, Immunologic; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/physiology; Signal Transduction/physiology; Structure-Activity Relationship; Ubiquitination

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Full text: 1 Database: MEDLINE Main subject: Polyubiquitin / Encephalomyocarditis virus / DEAD-box RNA Helicases Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2012 Type: Article Affiliation country: United States

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