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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Nat Immunol ; 13(8): 737-43, 2012 Jun 17.
Article in En | MEDLINE | ID: mdl-22706339
ABSTRACT
The innate immune system senses infection by detecting either evolutionarily conserved molecules essential for the survival of microbes or the abnormal location of molecules. Here we demonstrate the existence of a previously unknown innate detection mechanism induced by fusion between viral envelopes and target cells. Virus-cell fusion specifically stimulated a type I interferon response with expression of interferon-stimulated genes, in vivo recruitment of leukocytes and potentiation of signaling via Toll-like receptor 7 (TLR7) and TLR9. The fusion-dependent response was dependent on the stimulator of interferon genes STING but was independent of DNA, RNA and viral capsid. We suggest that membrane fusion is sensed as a danger signal with potential implications for defense against enveloped viruses and various conditions of giant-cell formation.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Interferon Type I / Cell Fusion / Herpesvirus 1, Human / Immunity, Innate / Membrane Fusion / Membrane Proteins Limits: Animals / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2012 Type: Article Affiliation country: Denmark

Full text: 1 Database: MEDLINE Main subject: Interferon Type I / Cell Fusion / Herpesvirus 1, Human / Immunity, Innate / Membrane Fusion / Membrane Proteins Limits: Animals / Humans Language: En Journal: Nat Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2012 Type: Article Affiliation country: Denmark