Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy.

Verheyen, An; Peeraer, Eve; Nuydens, Rony; Dhondt, Joke; Poesen, Koen; Pintelon, Isabel; Daniels, Anneleen; Timmermans, Jean-Pierre; Meert, Theo; Carmeliet, Peter; Lambrechts, Diether

Verheyen, An; Peeraer, Eve; Nuydens, Rony; Dhondt, Joke; Poesen, Koen; Pintelon, Isabel; Daniels, Anneleen; Timmermans, Jean-Pierre; Meert, Theo; Carmeliet, Peter; Lambrechts, Diether.

Affiliation

Verheyen A; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, B-3000 Leuven, Belgium.

Brain ; 135(Pt 9): 2629-41, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22734125

Subject(s)

Antibodies, Neutralizing/toxicity; Ganglia, Spinal/drug effects; Neuralgia/chemically induced; Polyneuropathies/chemically induced; Protein Kinase Inhibitors/toxicity; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Animals; Behavior, Animal/drug effects; Ganglia, Spinal/metabolism; Indoles/pharmacology; Mice; Mice, Transgenic; Neuralgia/metabolism; Neurons/metabolism; Paclitaxel/pharmacology; Pain Measurement; Polyneuropathies/metabolism; Protein Kinase Inhibitors/pharmacology; Pyrroles/pharmacology; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Database: MEDLINE Main subject: Polyneuropathies / Vascular Endothelial Growth Factor Receptor-2 / Protein Kinase Inhibitors / Antibodies, Neutralizing / Ganglia, Spinal / Neuralgia Limits: Animals Language: En Journal: Brain Year: 2012 Type: Article Affiliation country: Belgium

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