Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule.

Schroeder, Gottfried K; Zhou, Li; Snider, Mark J; Chen, Xian; Wolfenden, Richard

Schroeder, Gottfried K; Zhou, Li; Snider, Mark J; Chen, Xian; Wolfenden, Richard.

Affiliation

Schroeder GK; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA. gkschroeder@mail.utexas.edu

Biochemistry ; 51(32): 6476-86, 2012 Aug 14.

Article in En | MEDLINE | ID: mdl-22775299

Subject(s)

Cytidine Deaminase/antagonists & inhibitors; Cytidine Deaminase/chemistry; Enzyme Inhibitors/chemistry; Pyrimidine Nucleosides/chemistry; Water/chemistry; Calorimetry; Cytidine/analogs & derivatives; Cytidine/chemistry; Deamination; Dimerization; Fourier Analysis; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Kinetics; Mass Spectrometry; Protein Binding; Thermodynamics

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Database: MEDLINE Main subject: Pyrimidine Nucleosides / Water / Cytidine Deaminase / Enzyme Inhibitors Language: En Journal: Biochemistry Year: 2012 Type: Article Affiliation country: United States

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