Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.

Makowska-Grzyska, Magdalena; Kim, Youngchang; Wu, Ruiying; Wilton, Rosemarie; Gollapalli, Deviprasad R; Wang, Ximi K; Zhang, Rongguang; Jedrzejczak, Robert; Mack, Jamey C; Maltseva, Natalia; Mulligan, Rory; Binkowski, T Andrew; Gornicki, Piotr; Kuhn, Misty L; Anderson, Wayne F; Hedstrom, Lizbeth; Joachimiak, Andrzej

Makowska-Grzyska, Magdalena; Kim, Youngchang; Wu, Ruiying; Wilton, Rosemarie; Gollapalli, Deviprasad R; Wang, Ximi K; Zhang, Rongguang; Jedrzejczak, Robert; Mack, Jamey C; Maltseva, Natalia; Mulligan, Rory; Binkowski, T Andrew; Gornicki, Piotr; Kuhn, Misty L; Anderson, Wayne F; Hedstrom, Lizbeth; Joachimiak, Andrzej.

Affiliation

Makowska-Grzyska M; Center for Structural Genomics of Infectious Diseases, University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, USA.

Biochemistry ; 51(31): 6148-63, 2012 Aug 07.

Article in En | MEDLINE | ID: mdl-22788966

Subject(s)

Bacillus anthracis/enzymology; IMP Dehydrogenase/chemistry; IMP Dehydrogenase/metabolism; Inosine Monophosphate/metabolism; Ribonucleotides/metabolism; Amino Acid Sequence; Apoenzymes/antagonists & inhibitors; Apoenzymes/chemistry; Apoenzymes/metabolism; Benzimidazoles/chemistry; Benzimidazoles/metabolism; Benzimidazoles/pharmacology; Catalytic Domain; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Enzyme Inhibitors/pharmacology; IMP Dehydrogenase/antagonists & inhibitors; Models, Molecular; Molecular Sequence Data; Mycophenolic Acid/metabolism; NAD/metabolism; Protein Binding; Triazoles/chemistry; Triazoles/metabolism; Triazoles/pharmacology; Xanthine

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Full text: 1 Database: MEDLINE Main subject: Ribonucleotides / Bacillus anthracis / IMP Dehydrogenase / Inosine Monophosphate Language: En Journal: Biochemistry Year: 2012 Type: Article Affiliation country: United States

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