Compensatory molecular and functional mechanisms in nervous system of the Grm1(crv4) mouse lacking the mGlu1 receptor: a model for motor coordination deficits.

Rossi, Pia Irene Anna; Musante, Ilaria; Summa, Maria; Pittaluga, Anna; Emionite, Laura; Ikehata, Masami; Rastaldi, Maria Pia; Ravazzolo, Roberto; Puliti, Aldamaria

Rossi, Pia Irene Anna; Musante, Ilaria; Summa, Maria; Pittaluga, Anna; Emionite, Laura; Ikehata, Masami; Rastaldi, Maria Pia; Ravazzolo, Roberto; Puliti, Aldamaria.

Affiliation

Rossi PI; Molecular Genetics and Cytogenetics Unit, Gaslini Institute, Genoa, Italy.

Cereb Cortex ; 23(9): 2179-89, 2013 Sep.

Article in En | MEDLINE | ID: mdl-22791805

Subject(s)

Brain/physiopathology; Movement Disorders/physiopathology; Receptor, Metabotropic Glutamate 5/physiology; Receptors, Metabotropic Glutamate/deficiency; Animals; Brain/metabolism; Disease Models, Animal; Excitatory Amino Acid Antagonists/pharmacology; Female; Glutamic Acid/metabolism; Male; Mice; Mice, Inbred BALB C; Mutation; Pyridines/pharmacology; Receptor, Metabotropic Glutamate 5/antagonists & inhibitors; Receptor, Metabotropic Glutamate 5/metabolism; Synaptosomes/physiology

Key words

Grm1crv4 mouse; evoked-glutamate release; mGlu1 receptor; mGlu5 receptor; mouse cortex

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Full text: 1 Database: MEDLINE Main subject: Brain / Receptors, Metabotropic Glutamate / Receptor, Metabotropic Glutamate 5 / Movement Disorders Limits: Animals Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2013 Type: Article Affiliation country: Italy

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