Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence.

Gordon, Lavinia; Joo, Jihoon E; Powell, Joseph E; Ollikainen, Miina; Novakovic, Boris; Li, Xin; Andronikos, Roberta; Cruickshank, Mark N; Conneely, Karen N; Smith, Alicia K; Alisch, Reid S; Morley, Ruth; Visscher, Peter M; Craig, Jeffrey M; Saffery, Richard

Gordon, Lavinia; Joo, Jihoon E; Powell, Joseph E; Ollikainen, Miina; Novakovic, Boris; Li, Xin; Andronikos, Roberta; Cruickshank, Mark N; Conneely, Karen N; Smith, Alicia K; Alisch, Reid S; Morley, Ruth; Visscher, Peter M; Craig, Jeffrey M; Saffery, Richard.

Affiliation

Gordon L; Bioinformatics Unit, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia.

Genome Res ; 22(8): 1395-406, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22800725

Subject(s)

DNA Methylation; Epigenesis, Genetic; Fetal Development/genetics; Genome, Human; Twins, Dizygotic/genetics; Twins, Monozygotic/genetics; Cells, Cultured; CpG Islands; Epigenomics/methods; Female; Fetal Growth Retardation/genetics; Genetic Drift; Gestational Age; Human Umbilical Vein Endothelial Cells/cytology; Human Umbilical Vein Endothelial Cells/metabolism; Humans; Infant, Low Birth Weight; Infant, Newborn; Inheritance Patterns; Male; Oligonucleotide Array Sequence Analysis; Organ Specificity; Phenotype; Placenta/cytology; Placenta/metabolism; Pregnancy; Regression Analysis; Stochastic Processes

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Full text: 1 Database: MEDLINE Main subject: Twins, Dizygotic / Twins, Monozygotic / Genome, Human / DNA Methylation / Epigenesis, Genetic / Fetal Development Type of study: Diagnostic_studies Limits: Female / Humans / Male / Newborn / Pregnancy Language: En Journal: Genome Res Journal subject: BIOLOGIA MOLECULAR / GENETICA Year: 2012 Type: Article Affiliation country: Australia

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