The p110&#945; and p110ß isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.

Utermark, Tamara; Rao, Trisha; Cheng, Hailing; Wang, Qi; Lee, Sang Hyun; Wang, Zhigang C; Iglehart, J Dirk; Roberts, Thomas M; Muller, William J; Zhao, Jean J

The p110α and p110ß isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.

Utermark, Tamara; Rao, Trisha; Cheng, Hailing; Wang, Qi; Lee, Sang Hyun; Wang, Zhigang C; Iglehart, J Dirk; Roberts, Thomas M; Muller, William J; Zhao, Jean J.

Affiliation

Utermark T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

Genes Dev ; 26(14): 1573-86, 2012 Jul 15.

Article in En | MEDLINE | ID: mdl-22802530

Subject(s)

Cell Transformation, Neoplastic/metabolism; Class I Phosphatidylinositol 3-Kinases/metabolism; Mammary Glands, Animal/enzymology; Mammary Neoplasms, Animal/enzymology; Animals; Antigens, Viral, Tumor/genetics; Antigens, Viral, Tumor/metabolism; Cell Transformation, Neoplastic/genetics; Class I Phosphatidylinositol 3-Kinases/genetics; Female; Mammary Glands, Animal/growth & development; Mammary Glands, Animal/pathology; Mammary Neoplasms, Animal/genetics; Mammary Neoplasms, Animal/pathology; Mice; Mice, Transgenic; Polyomavirus/genetics; Polyomavirus/metabolism; Receptor, ErbB-2/genetics; Receptor, ErbB-2/metabolism

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Full text: 1 Database: MEDLINE Main subject: Mammary Neoplasms, Animal / Cell Transformation, Neoplastic / Class I Phosphatidylinositol 3-Kinases / Mammary Glands, Animal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2012 Type: Article Affiliation country: United States

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