Population stratification may bias analysis of PGC-1&#945; as a modifier of age at Huntington disease motor onset.

Ramos, Eliana Marisa; Latourelle, Jeanne C; Lee, Ji-Hyun; Gillis, Tammy; Mysore, Jayalakshmi S; Squitieri, Ferdinando; Di Pardo, Alba; Di Donato, Stefano; Hayden, Michael R; Morrison, Patrick J; Nance, Martha; Ross, Christopher A; Margolis, Russell L; Gomez-Tortosa, Estrella; Ayuso, Carmen; Suchowersky, Oksana; Trent, Ronald J; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Jones, Randi; Ashizawa, Tetsuo; Frank, Samuel; Saint-Hilaire, Marie-Helene; Hersch, Steven M; Rosas, Herminia D; Lucente, Diane; Harrison, Madaline B; Zanko, Andrea; Marder, Karen; Gusella, James F; Lee, Jong-Min; Alonso, Isabel; Sequeiros, Jorge; Myers, Richard H; Macdonald, Marcy E

Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset.

Ramos, Eliana Marisa; Latourelle, Jeanne C; Lee, Ji-Hyun; Gillis, Tammy; Mysore, Jayalakshmi S; Squitieri, Ferdinando; Di Pardo, Alba; Di Donato, Stefano; Hayden, Michael R; Morrison, Patrick J; Nance, Martha; Ross, Christopher A; Margolis, Russell L; Gomez-Tortosa, Estrella; Ayuso, Carmen; Suchowersky, Oksana; Trent, Ronald J; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Jones, Randi; Ashizawa, Tetsuo; Frank, Samuel; Saint-Hilaire, Marie-Helene; Hersch, Steven M; Rosas, Herminia D; Lucente, Diane; Harrison, Madaline B; Zanko, Andrea; Marder, Karen; Gusella, James F; Lee, Jong-Min; Alonso, Isabel; Sequeiros, Jorge; Myers, Richard H; Macdonald, Marcy E.

Affiliation

Ramos EM; Center for Human Genetic Research, Massachusetts General Hospital, Simches Research Building, Room 5414, 185 Cambridge Street, Boston, MA 02114, USA.

Hum Genet ; 131(12): 1833-40, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22825315

Subject(s)

Heat-Shock Proteins/genetics; Huntington Disease/genetics; Polymorphism, Single Nucleotide; Transcription Factors/genetics; Adult; Age of Onset; Cohort Studies; Europe/epidemiology; Female; Genetics, Population; Humans; Huntingtin Protein; Huntington Disease/epidemiology; Male; Middle Aged; Nerve Tissue Proteins/genetics; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Trinucleotide Repeat Expansion

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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Huntington Disease / Polymorphism, Single Nucleotide / Heat-Shock Proteins Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Hum Genet Year: 2012 Type: Article Affiliation country: United States

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