Thumbs down for HIV: domain level rearrangements do occur in the NNRTI-bound HIV-1 reverse transcriptase.

Wright, David W; Sadiq, S Kashif; De Fabritiis, Gianni; Coveney, Peter V

Wright, David W; Sadiq, S Kashif; De Fabritiis, Gianni; Coveney, Peter V.

Affiliation

Wright DW; Centre for Computational Science, Department of Chemistry, University College London , London WC1H 0AJ, U.K.

J Am Chem Soc ; 134(31): 12885-8, 2012 Aug 08.

Article in En | MEDLINE | ID: mdl-22827470

Subject(s)

Benzoxazines/chemistry; HIV Reverse Transcriptase/chemistry; Reverse Transcriptase Inhibitors/chemistry; Alkynes; Allosteric Regulation; Allosteric Site; Binding Sites; Crystallography, X-Ray; Cyclopropanes; HIV-1/enzymology; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation/drug effects

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Reverse Transcriptase Inhibitors / Benzoxazines / HIV Reverse Transcriptase Language: En Journal: J Am Chem Soc Year: 2012 Type: Article Affiliation country: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google