The defect in humoral immunity in patients with Nijmegen breakage syndrome is explained by defects in peripheral B lymphocyte maturation.

Piatosa, Barbara; van der Burg, Mirjam; Siewiera, Katarzyna; Pac, Malgorzata; van Dongen, Jacques J M; Langerak, Anton W; Chrzanowska, Krystyna H; Bernatowska, Ewa

Piatosa, Barbara; van der Burg, Mirjam; Siewiera, Katarzyna; Pac, Malgorzata; van Dongen, Jacques J M; Langerak, Anton W; Chrzanowska, Krystyna H; Bernatowska, Ewa.

Affiliation

Piatosa B; Histocompatibility Laboratory, Children's Memorial Health Institute, Warsaw, Poland. b.piatosa@czd.pl

Cytometry A ; 81(10): 835-42, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22851427

Subject(s)

B-Lymphocyte Subsets/immunology; B-Lymphocytes/immunology; Cell Cycle Proteins/immunology; Immunity, Humoral; Nijmegen Breakage Syndrome/immunology; Nuclear Proteins/immunology; Adolescent; B-Lymphocyte Subsets/pathology; B-Lymphocytes/pathology; Cell Cycle Proteins/genetics; Cell Differentiation/genetics; Cell Differentiation/immunology; Child; Child, Preschool; Flow Cytometry; Gene Expression/immunology; Humans; Immunoglobulin A/blood; Immunoglobulin Class Switching; Immunoglobulin G/blood; Immunoglobulin M/blood; Immunologic Memory; Immunophenotyping; Infant; Lymphocyte Count; Nijmegen Breakage Syndrome/genetics; Nijmegen Breakage Syndrome/pathology; Nuclear Proteins/genetics; T-Lymphocytes/immunology; T-Lymphocytes/pathology

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Full text: 1 Database: MEDLINE Main subject: Nuclear Proteins / B-Lymphocytes / B-Lymphocyte Subsets / Cell Cycle Proteins / Nijmegen Breakage Syndrome / Immunity, Humoral Limits: Adolescent / Child / Child, preschool / Humans / Infant Language: En Journal: Cytometry A Year: 2012 Type: Article Affiliation country: Poland

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