Responsiveness to low-dose warfarin associated with genetic variants of VKORC1, CYP2C9, CYP2C19, and CYP4F2 in an Indonesian population.

Rusdiana, T; Araki, T; Nakamura, T; Subarnas, A; Yamamoto, K

Rusdiana, T; Araki, T; Nakamura, T; Subarnas, A; Yamamoto, K.

Affiliation

Rusdiana T; Department of Clinical Pharmacology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Japan. taofikr@unpad.ac.id

Eur J Clin Pharmacol ; 69(3): 395-405, 2013 Mar.

Article in En | MEDLINE | ID: mdl-22855348

Subject(s)

Anticoagulants/pharmacokinetics; Aryl Hydrocarbon Hydroxylases/genetics; Asian People/genetics; Blood Coagulation/drug effects; Cytochrome P-450 Enzyme System/genetics; Genetic Variation; Mixed Function Oxygenases/genetics; Warfarin/pharmacokinetics; Adult; Age Factors; Aged; Aged, 80 and over; Anticoagulants/administration & dosage; Anticoagulants/blood; Aryl Hydrocarbon Hydroxylases/metabolism; Biotransformation; Chi-Square Distribution; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System/metabolism; Cytochrome P450 Family 4; Drug Monitoring/methods; Female; Gene Frequency; Genotype; Humans; Indonesia/epidemiology; International Normalized Ratio; Linear Models; Male; Middle Aged; Mixed Function Oxygenases/metabolism; Multivariate Analysis; Pharmacogenetics; Phenotype; Prothrombin Time; Vitamin K Epoxide Reductases; Warfarin/administration & dosage; Warfarin/analogs & derivatives; Warfarin/blood; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Genetic Variation / Warfarin / Blood Coagulation / Aryl Hydrocarbon Hydroxylases / Cytochrome P-450 Enzyme System / Asian People / Mixed Function Oxygenases / Anticoagulants Type of study: Prognostic_studies / Risk_factors_studies Limits: Aged80 Country/Region as subject: Asia Language: En Journal: Eur J Clin Pharmacol Year: 2013 Type: Article Affiliation country: Japan

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