Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of &#945;-smooth muscle actin filaments during myofibroblast differentiation.

Cai, Guo-Qiang; Chou, Chu-Fang; Hu, Meng; Zheng, Anni; Reichardt, Louis F; Guan, Jun-Lin; Fang, Haotian; Luckhardt, Tracy R; Zhou, Yong; Thannickal, Victor J; Ding, Qiang

Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation.

Cai, Guo-Qiang; Chou, Chu-Fang; Hu, Meng; Zheng, Anni; Reichardt, Louis F; Guan, Jun-Lin; Fang, Haotian; Luckhardt, Tracy R; Zhou, Yong; Thannickal, Victor J; Ding, Qiang.

Affiliation

Cai GQ; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Am J Physiol Lung Cell Mol Physiol ; 303(8): L692-702, 2012 Oct 15.

Article in En | MEDLINE | ID: mdl-22886502

Subject(s)

Actin Cytoskeleton/metabolism; Actins/metabolism; Fibroblasts/metabolism; Pulmonary Fibrosis/metabolism; Wiskott-Aldrich Syndrome Protein, Neuronal/metabolism; Actin Cytoskeleton/drug effects; Actin-Related Protein 3/metabolism; Animals; Cell Differentiation/drug effects; Cell Differentiation/physiology; Collagen/metabolism; Cytoplasm/metabolism; Fibroblasts/cytology; Focal Adhesion Kinase 1/metabolism; Lung/cytology; Lung/metabolism; Mice; Mice, Inbred C57BL; Phosphorylation/drug effects; Phosphorylation/physiology; Primary Cell Culture; Pulmonary Fibrosis/pathology; RNA, Small Interfering/genetics; Transforming Growth Factor beta1/pharmacology; Tyrosine/metabolism; Wiskott-Aldrich Syndrome Protein, Neuronal/genetics

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Full text: 1 Database: MEDLINE Main subject: Pulmonary Fibrosis / Actin Cytoskeleton / Actins / Wiskott-Aldrich Syndrome Protein, Neuronal / Fibroblasts Limits: Animals Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2012 Type: Article Affiliation country: United States

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