Pharmacodynamics, safety, and pharmacokinetics of BMS-663068, an oral HIV-1 attachment inhibitor in HIV-1-infected subjects.

Nettles, Richard E; Schürmann, Dirk; Zhu, Li; Stonier, Michele; Huang, Shu-Pang; Chang, Ih; Chien, Caly; Krystal, Mark; Wind-Rotolo, Megan; Ray, Neelanjana; Hanna, George J; Bertz, Richard; Grasela, Dennis

Nettles, Richard E; Schürmann, Dirk; Zhu, Li; Stonier, Michele; Huang, Shu-Pang; Chang, Ih; Chien, Caly; Krystal, Mark; Wind-Rotolo, Megan; Ray, Neelanjana; Hanna, George J; Bertz, Richard; Grasela, Dennis.

Affiliation

Nettles RE; Research and Development, Bristol-Myers Squibb (BMS), Princeton, New Jersey 08534, USA.

J Infect Dis ; 206(7): 1002-11, 2012 Oct 01.

Article in En | MEDLINE | ID: mdl-22896665

Subject(s)

HIV Fusion Inhibitors/therapeutic use; HIV Infections/drug therapy; HIV-1/drug effects; Organophosphates/therapeutic use; Piperazines/therapeutic use; Adult; Aged; Area Under Curve; Drug Therapy, Combination; Female; HIV Fusion Inhibitors/adverse effects; HIV Fusion Inhibitors/pharmacokinetics; HIV Infections/blood; HIV Infections/virology; HIV Protease Inhibitors/therapeutic use; HIV-1/genetics; Humans; Inhibitory Concentration 50; Male; Middle Aged; Organophosphates/adverse effects; Organophosphates/pharmacokinetics; Piperazines/adverse effects; Piperazines/pharmacokinetics; RNA, Viral/blood; Ritonavir/therapeutic use; Treatment Outcome; Viral Load/drug effects; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Organophosphates / Piperazines / HIV Infections / HIV-1 / HIV Fusion Inhibitors Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Infect Dis Year: 2012 Type: Article Affiliation country: United States

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