Alzheimer Disease/complications; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Memory Disorders/etiology; Memory Disorders/metabolism; Ryanodine Receptor Calcium Release Channel/metabolism; Alzheimer Disease/genetics; Aminophenols/therapeutic use; Amyloid Precursor Protein Secretases/genetics; Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/metabolism; Analysis of Variance; Animals; Brain/cytology; Caffeine/pharmacology; Calcium/metabolism; Calcium Channel Blockers/therapeutic use; Cells, Cultured; Cytosol/drug effects; Cytosol/metabolism; Dantrolene/pharmacology; Disease Models, Animal; Embryo, Mammalian; Endoplasmic Reticulum/drug effects; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum/pathology; Enzyme Inhibitors/therapeutic use; Exploratory Behavior/drug effects; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Humans; Inositol 1,4,5-Trisphosphate Receptors/genetics; Inositol 1,4,5-Trisphosphate Receptors/metabolism; Maleimides/therapeutic use; Maze Learning/drug effects; Membrane Potentials/drug effects; Membrane Potentials/genetics; Membrane Proteins/metabolism; Memory Disorders/drug therapy; Mice; Mice, Transgenic; Muscle Relaxants, Central/pharmacology; Mutation/genetics; Nerve Tissue Proteins/metabolism; Neuroblastoma/pathology; Neurons/drug effects; Neurons/physiology; Patch-Clamp Techniques; Peptide Fragments/metabolism; Phosphorylation/drug effects; Phosphorylation/genetics; Plaque, Amyloid/metabolism; Plaque, Amyloid/pathology; Purines/therapeutic use; RNA, Messenger/metabolism