IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.

Hodge, Lucy S; Ziesmer, Steve C; Yang, Zhi Zhang; Secreto, Frank J; Gertz, Morie A; Novak, Anne J; Ansell, Stephen M

Hodge, Lucy S; Ziesmer, Steve C; Yang, Zhi Zhang; Secreto, Frank J; Gertz, Morie A; Novak, Anne J; Ansell, Stephen M.

Affiliation

Hodge LS; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Blood ; 120(18): 3774-82, 2012 Nov 01.

Article in En | MEDLINE | ID: mdl-22976953

Subject(s)

Cell Proliferation; Immunoglobulin M/biosynthesis; Interleukins/metabolism; Tumor Microenvironment/immunology; Waldenstrom Macroglobulinemia/metabolism; Waldenstrom Macroglobulinemia/pathology; Bone Marrow/immunology; Bone Marrow/metabolism; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunoblotting; Immunoglobulin M/immunology; Immunohistochemistry; Interleukins/immunology; Lymphocyte Activation/immunology; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/immunology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; Waldenstrom Macroglobulinemia/immunology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Immunoglobulin M / Interleukins / Waldenstrom Macroglobulinemia / Cell Proliferation / Tumor Microenvironment Limits: Humans Language: En Journal: Blood Year: 2012 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google