Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.

Verbeeck, Christophe; Deng, Qiudong; Dejesus-Hernandez, Mariely; Taylor, Georgia; Ceballos-Diaz, Carolina; Kocerha, Jannet; Golde, Todd; Das, Pritam; Rademakers, Rosa; Dickson, Dennis W; Kukar, Thomas

Verbeeck, Christophe; Deng, Qiudong; Dejesus-Hernandez, Mariely; Taylor, Georgia; Ceballos-Diaz, Carolina; Kocerha, Jannet; Golde, Todd; Das, Pritam; Rademakers, Rosa; Dickson, Dennis W; Kukar, Thomas.

Affiliation

Verbeeck C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.

Mol Neurodegener ; 7: 53, 2012 Oct 10.

Article in En | MEDLINE | ID: mdl-23046583

Subject(s)

Amyotrophic Lateral Sclerosis/genetics; Nerve Degeneration/genetics; Nerve Degeneration/pathology; RNA-Binding Protein FUS/genetics; Amyotrophic Lateral Sclerosis/metabolism; Amyotrophic Lateral Sclerosis/pathology; Animals; Brain/metabolism; Brain/pathology; Disease Models, Animal; Humans; Immunohistochemistry; Inclusion Bodies/genetics; Inclusion Bodies/metabolism; Inclusion Bodies/pathology; Mice; Mice, Transgenic; Mutation; Nerve Degeneration/metabolism; Neurons/metabolism; Neurons/pathology; RNA-Binding Protein FUS/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: RNA-Binding Protein FUS / Amyotrophic Lateral Sclerosis / Nerve Degeneration Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Mol Neurodegener Year: 2012 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google