Effects of rifampin and mefenamic acid on the pharmacokinetics and pharmacodynamics of dapagliflozin.

Kasichayanula, S; Liu, X; Griffen, S C; Lacreta, F P; Boulton, D W

Kasichayanula, S; Liu, X; Griffen, S C; Lacreta, F P; Boulton, D W.

Affiliation

Kasichayanula S; Discovery Medicine & Clinical Pharmacology, Bristol-Myers Squibb, Princeton, NJ, USA. sreeneeranj.kasichayanula@bms.com

Diabetes Obes Metab ; 15(3): 280-3, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23061428

Subject(s)

Diabetes Mellitus, Type 2/drug therapy; Enzyme Inhibitors/pharmacology; Glucosides/pharmacokinetics; Glucuronosyltransferase/metabolism; Hypoglycemic Agents/pharmacokinetics; Mefenamic Acid/pharmacology; Rifampin/pharmacology; Sodium-Glucose Transporter 2 Inhibitors; Adolescent; Adult; Benzhydryl Compounds; Body Mass Index; Diabetes Mellitus, Type 2/metabolism; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors/administration & dosage; Female; Glucosides/administration & dosage; Glucuronosyltransferase/drug effects; Humans; Hypoglycemic Agents/administration & dosage; Male; Mefenamic Acid/administration & dosage; Middle Aged; Rifampin/administration & dosage; Signal Transduction/drug effects; Sodium-Glucose Transporter 2; UDP-Glucuronosyltransferase 1A9

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Full text: 1 Database: MEDLINE Main subject: Rifampin / Mefenamic Acid / Glucuronosyltransferase / Diabetes Mellitus, Type 2 / Enzyme Inhibitors / Sodium-Glucose Transporter 2 Inhibitors / Glucosides / Hypoglycemic Agents Type of study: Clinical_trials Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Diabetes Obes Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2013 Type: Article Affiliation country: United States

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