T-type Ca2+ channel blocker, KYS05047 induces G1 phase cell cycle arrest by decreasing intracellular Ca2+ levels in human lung adenocarcinoma A549 cells.

Rim, Hong-Kun; Lee, Heon-Woo; Choi, Il Sook; Park, Jin Yeong; Choi, Heung Woo; Choi, Jung-Hye; Cho, Young-Wuk; Lee, Jae Yeol; Lee, Kyung-Tae

Rim, Hong-Kun; Lee, Heon-Woo; Choi, Il Sook; Park, Jin Yeong; Choi, Heung Woo; Choi, Jung-Hye; Cho, Young-Wuk; Lee, Jae Yeol; Lee, Kyung-Tae.

Affiliation

Rim HK; Department of Pharmaceutical Biochemistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.

Bioorg Med Chem Lett ; 22(23): 7123-6, 2012 Dec 01.

Article in En | MEDLINE | ID: mdl-23079520

Subject(s)

Calcium Channel Blockers/pharmacology; Calcium Channels, T-Type/chemistry; Calcium/metabolism; G1 Phase Cell Cycle Checkpoints/drug effects; Quinazolines/pharmacology; Adenocarcinoma/drug therapy; Adenocarcinoma of Lung; Animals; Calcium Channel Blockers/chemistry; Calcium Channel Blockers/therapeutic use; Calcium Channels, T-Type/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Cyclin-Dependent Kinase 2/metabolism; Cyclin-Dependent Kinase 4/metabolism; Humans; Lung Neoplasms/drug therapy; Mice; Mice, Inbred BALB C; Quinazolines/chemistry; Quinazolines/therapeutic use; Transplantation, Heterologous

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Full text: 1 Database: MEDLINE Main subject: Quinazolines / Calcium Channel Blockers / Calcium / Calcium Channels, T-Type / G1 Phase Cell Cycle Checkpoints Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article

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